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| Departments and Laboratories: |
 
 
Arcaded Passage of the Clothier's Hall (Cracow)
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Department of Medicinal Chemistry
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| Scope of Research
| Methods
| Cooperation
| Research Staff |
Head: Assoc. Prof. Andrzej Bojarski
Phone: (+48 12) 66 23 365
E-mail: bojarski@if-pan.krakow.pl
Scope of Research
- structure-activity relationship (SAR) of centrally acting agents;
- computer-aided drug design;
- design and search for new antidepressant and anxiolytic agents;
- G-protein-coupled receptors;
- molecular mechanism of ligand-receptor interactions;
- molecular modelling;
- heterocyclic chemistry;
- stereochemistry and conformational analysis of organic compounds.
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Methods
- Organic synthesis:
alkylation of amines and amides;
amide bond formation;
reduction and oxidation processes;
synthesis of heterocyclic ring systems;
benzotriazole as a synthon in N- or C-alkylation.
- Biochemical:
radioligand binding to various subtypes of serotonergic (5-HT1A, 5-HT2A, 5HT7), adrenergic (alpha1 and alpha2) dopaminergic (D1 and D2 receptors.
- Molecular modelling:
homology modelling of GPCR;
ligand docking;
advanced methods of a computer analysis of drug-receptor interaction;
theoretical conformational analysis;
calculation of some physico-chemical parameters of organic molecules.
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International Cooperation
The Department cooperates with:
- the Department of Chemistry, Georgia State University, Atlanta (USA)
- - quantitative structure activity relationships studies in the group of substituted 2-phenylquinolin-4-amines, antagonists of immunostimulatory CpG-oligodeoxynucleotides;
- Pharmacy Department, University Hospital Centre, Lausanne (Switzerland)
- - the examination of the phenomenon of „dissolvance” (constraints experienced by components of a complex system as a result of their transactions).
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Research Staff:
Engineers, Technicians, and Other Employees:
| Name |
E-mail |
Phone (+4812) |
| Aneta Kozioł |
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66 23 214 |
| Krystyna Nędza |
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66 23 214 |
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