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| Departments and Laboratories: |
 
 
The City Hall Tower (Cracow)
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Department of Neurochemistry
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| Scope of Research
| Methods
| Cooperation
| Research Staff |
Head: Prof. Lucyna Antkiewicz-Michaluk
Phone: (+48 12) 66 23 203
E-mail: antkiew@if-pan.krakow.pl
Scope of Research:
ENDOGENUS TETRAHYDROISOQUINOLINES (TIQs)
- the physiological role and pharmacological potential of endogenous tetrahydroisoquinolines:
behavioral and neurochemical studies;
PARKINSON'S DISEASE
Animal models of PD
- rotenone;
- neurotoxic tetrahydroisoquinolines (salsolinol, 1BnTIQ);
- dopamine metabolism and release (in vivo as a target for neurotoxic and neuroprotective agents;
ADDICTION
- behavioral and neurochemical correlates of craving and drug dependence (cocaine, morphine);
- neuroprotective tetrahydroisoquinolines (TIQ, 1MeTIQ) as antiadditive agents;
- 3-metoxytyramine (3-MT) and its physiological role in dopamine stimulation and drug addiction:
behavioral and molecular studies.
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Methods
- Biochemical:
radioligand binding assay;
the HPLC analysis of biogenic amines (dopamine, noradrenaline, serotonin) and their metabolites (DOPAC, 3-MT, HVA; MOPEG, 5-HIAA);
assessment of metabolic rates;
assay of monoamine tissue uptake;
assay of MAO activity;
in vivo microdialysis study.
- Behavioural:
locomotor activity and stereotypy;
catalepsy;
tail flick and hot plate tests;
Porsolt’s test;
instrumental treatments - electroconvulsive shock.
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International Cooperation
The Department cooperates with:
- the CNR Institute of Psychobiology and Psychopharmacology in Rome (Italy)
- - studies on the physiological role of 1,2,3,4-tetrahydroisoquinolines in CNS of rodents;
- the Department of Psychiatry & Human Behavior, University of Mississippi Medical Center in Jackson (USA)
- - studies on the role of NOS inhibitor in the mechanism of action of antidepressant drugs.
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Research Staff:
PhD Students:
Engineers, Technicians, and Other Employees:
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