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| Departments and Laboratories: |
 
 
St. Adalbert's Church in the Market Square (Cracow)
Market Square at night (Cracow)
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Department of Neuro- and Psychopharmacology
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| Scope of Research
| Methods
| Cooperation
| Research Staff |
Head: Prof. Krystyna Ossowska
Phone: (+48 12) 66 23 321
E-mail: ossowska@if-pan.krakow.pl
Scope of Research
- role of central dopaminergic, glutamatergic, GABAergic and adenosine receptors in Parkinson’s disease - animal models of disease symptoms;
- role of dopaminergic, glutamatergic and adenosine receptors in animal models of psychotic disorders;
- neurotransmitter receptors and drug effects;
- mechanisms connected with antipsychotic and extrapyramidal effects of neuroleptics and related compounds;
- the long-term effects of drug action;
- the neurotoxic effects of substances which may be responsible for Parkinson’s disease;
- the central and peripheral mechanism of aging.
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Methods
- Behavioural:
catalepsy, stereotypy and motility measurement;
tests for motor coordination;
rotational behaviour;
muscle resistance to passive movements (mechanomyogram);
prepulse inhibition of the startle response to an acoustic stimulus.
- Biochemical:
the characteristic and localization of receptors in brain structures;
the autoradiography of receptor binding;
in situ hybridization;
computer image analysis (MCID system);
the Western blot.
- Stereotaxic:
the implantation of chronic cannula into brain structures;
microinjections into the brain;
chemical lesions of the brain.
- Electrophysiological:
electromyogram (EMG).
- Histological:
immunohistochemistry;
verification of brain lesions and microinjection sites.
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International Cooperation
The Department cooperates with:
- the Section of the Clinical Neurobiology Charite in Berlin (Germany)
- - studies on the pathomechanism of Parkinson’s disease;
- the Institute of Pharmacology and Toxicology of the Leipzig University (Germany)
- - investigations of the pathomechanism of Parkinson’s disease;
- the Department of Toxicology, University of Cagliari (Italy)
- - studies on the interaction between dopamine and adenosine receptors;
- the Institute of Physiology of the Bulgarian Academy of Sciences, Sofia (Bulgaria)
- - search for the new strategy in Parkinson’s disease therapy.
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Research Staff:
PhD Students:
Engineers, Technicians, and Other Employees:
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