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| Departments and Laboratories: |
 
 
View from the St. Mary's Square (Cracow)
Look at the Royal Cathedral on the Wawel Hill (Cracow)
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Department of Pharmacology of Pain
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| Scope of Research
| Methods
| Cooperation
| Research Staff |
Head: Prof. Barbara Przewłocka
Phone: (+48 12) 66 23 398
E-mail: przebar@if-pan.krakow.pl
Scope of Research:
- the role of endogenous opioid peptides in physiology and pathology of the central and peripheral nervous system;
- investigation of new drugs in acute and chronic pain animals models; search of new pain therapy;
- pharmacological and biochemical analysis of endogenous neuropeptide system activities in acute and chronic nociceptive processes.
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Methods
- Behavioural:
tests for measurement of nociceptive threshold (thermal and mechanical nociceptive stimuli) in rats and mice;
tests for measurement of nociception (allodynia and hyperalgesia) in chronic pain e.g. inflammatory and neuropathic pain models; plethysmometry; joint inflammation;
animal models of drug tolerance and dependence.
- Stereotaxic brain and spinal cord surgery:
implantation of chronic cannulae in different brain areas;
intrathecal implantations in the spinal cord.
- Biochemical:
measurement of gene expression engaged in opioid effectiveness (in situ hybridization, Northern blot, Western blot;
computer image analysis (MCID); immunohistochemistry.
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International Cooperation
The Department cooperates with:
- the Institute of Neuroscience, CNR, Rome (Italy)
- - studies on nociceptive processes in genetically different strains of mice;
- the Institute of Biochemistry of the Hungarian Academy of Sciences, Szeged (Hungary)
- - studies on biological characteristics of novel opioid receptor ligands;
- the Institute of Anatomy and Cell Biology of the Philipps University in Marburg (Germany)
- - examining the role of spinal cord neuropeptide systems in pathological pain;
- the Rudolph Magnus Institute of the Utrecht University (the Netherlands)
- - studies on the interaction between melanocortin and opioid systems in nociceptive processes.
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Research Staff:
PhD Students:
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