 |
| Departments and Laboratories: |
 
 
The Clothier's Hall in the Market Square (Cracow)
Inside of the Clothier's Hall (Cracow)
|
|
|
Department of Physiology
|
|
| Scope of Research
| Methods
| Cooperation
| Research Staff |
Head: Prof. Grzegorz Hess
Phone: (+48 12) 66 23 212
E-mail: hess@if-pan.krakow.pl
Scope of Research
- adaptive modification in the responsiveness of hippocampal and frontal cortical neurons to 5-hydroxytryptamine induced by repeated treatment with psychotropic drugs and corticosterone;
- adaptive modifications of glutamatergic transmission in the frontal cortex induced by antidepressant treatments and corticosterone;
- the influence of repeated treatment with psychotropic drugs and corticosterone on synaptic plasticity in the hippocampus;
- cellular mechanisms of aversive training-induced plasticity of the somatosensory cortex;
- the significance of prostaglandins (PG) generated by constitutive and inducible cyclooxygenase in the corticotropin releasing hormone (CRH) and vasopressin (AVP)-induced activity of the hypothalamic-pituitary-adrenocortical (HPA) axis during chronic social stress;
- the role of neurotransmitters in the central regulation of the HPA under basal and stress conditions.
Back to Top
Methods
- Electrophysiological:
whole cell patch clamp and extracellular recording from neurons in brain slices in vitro.
- Behavioural:
models of stress - repeated handling, restraint stress and chronic social crowding.
- Biochemical:
assessment of neurotransmitters and their metabolites by HPLC;
the spectrofluorometric assay of corticosterone;
the radioimmunoassay of ACTH in plasma.
Back to Top
International Cooperation
The Department cooperates with:
- the Institute of Physiology and Pathophysiology, University of Heidelberg (Germany)
- - investigation of the effect of stress on synaptic plasticity.
Back to Top
Research Staff:
PhD Students:
Engineers, Technicians, and Other Employees:
|
|
;)
;)
