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Copyright © 2000 by Institute of Pharmacology Polish Academy of Sciences |
Pol. J. Pharmacol., 2000, 52, 111-114 ISSN 1230-6002 |
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Synergistic effect of amantadine and imipramine in the forced swimming test.
J. MAJ, Z. ROGÓZ. Pol. J. Pharmacol., 2000, 52, 111–114. The obtained results indicate that joint administration of amantadine (a non-competitive NMDA receptor antagonist) and imipramine induced antidepressant-like effect in the forced swimming test even at doses of both drugs which were ineffective when each of the drugs was used alone. Key words: corticosterone, serotonin, 5-HT4 receptor, hippocampus |
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