CONTENTS (PDF format)

Review - Neuronal autophagy in cerebral ischemia – a potential target for neuroprotective strategies? Bożena Gabryel, Alicja Kost, Daniela Kasprowska (p. 1) Abstract / Article (PDF format) Review - Chemical structure of phenothiazines and their biological activity. Agata Jaszczyszyn, Kazimierz Gąsiorowski, Piotr Świątek, Wiesław Malinka, Katarzyna Cieślik-Boczula, Joanna Petrus, Bogusława Czarnik-Matusewicz (p. 16) Abstract / Article (PDF format) Review - What’s the role of topiramate in the management of patients with hyperkinetic movement disorders? Antonio Siniscalchi, Luca Galeli, Chiara Giofre, Giovambattista De Sarro (p. 24) Abstract / Article (PDF format) Review - Animal models of acute renal failure. Amrit Pal Singh, Arunachalam Muthuraman, Amteshwar Singh Jaggi, Nirmal Singh, Kuldeep Grover, Ravi Dhawan (p. 31) Abstract / Article (PDF format) Anxiogenic effect of CCK8s in the ventral hippocampus of rats: possible involvement of GABAA receptors. Akbar Hajizadeh Moghaddam, Robabeh Sadat Hosseini, Ali Roohbakhsh (p. 45) Abstract / Article (PDF format) Anxiolytic-like effect of losartan injected into amygdala of the acutely stressed rats. Luis H. Llano López, Fernando Caif, Sebastián García, Miriam Fraile, Adriana I. Landa, Gustavo Baiardi, José V. Lafuente, Jan J. Braszko, Claudia Bregonzio, Pascual A. Gargiulo (p. 54) Abstract / Article (PDF format) Sub-chronic exposure to noise affects locomotor activity and produces anxiogenic and depressive like behavior in rats. Fizza Naqvi, Saida Haider, Zehra Batool, Tahira Perveen, Darakhshan J. Haleem (p. 64) Abstract / Article (PDF format) Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context. Roberta Zancheta, Ana P.M. Possi, Cleopatra S. Planeta, Marcelo T. Marin (p. 70) Abstract / Article (PDF format) Chronic ethanol tolerance as a result of free-choice drinking in alcohol-preferring rats of the WHP line. Wanda Dyr, Ewa Taracha (p. 78) Abstract / Article (PDF format) Analgesia and serum assays of controlled-release dihydrocodeine and metabolites in cancer patients with pain. Wojciech Leppert, Przemysław Mikołajczak, Ewa Kamińska, Michał Szulc (p. 84) Abstract / Article (PDF format) Central effect of crocin on penicillin-induced epileptiform activity in rats. Esmaeal Tamaddonfard, Nasrin Hamzeh Gooshchi, Sona Seiednejad-Yamchi (p. 94) Abstract / Article (PDF format) Analgesic and anticonvulsant activity of new derivatives of 2-substituted 4-hydroxybutanamides in mice. Kinga Sałat, Katarzyna Kulig, Robert Sałat, Barbara Filipek, Barbara Malawska (p. 102) Abstract / Article (PDF format) Pharmacokinetics and pharmacodynamics of propofol in patients undergoing abdominal aortic surgery. Paweł Wiczling, Agnieszka Bienert, Paweł Sobczyński, Roma Hartmann-Sobczyńska, Krzysztof Bieda, Aleksandra Marcinkowska, Maria Malatyńska, Roman Kaliszan, Edmund Grześkowiak (p. 113) Abstract / Article (PDF format) Influence of 825 C>T polymorphism of G protein beta3 subunit gene (GNB3) on hemodynamic response during dobutamine stress echocardiography. Anna Banaś, Edyta Płońska, Barbara Larysz, Mateusz Kurzawski, Marek Droździk (p. 123) Abstract / Article (PDF format) Fructose-fed streptozotocin-injected rat: an alternative model for type 2 diabetes. Rachel D. Wilson, Md. Shahidul Islam (p. 129) Abstract / Article (PDF format) Exendin-4 reduces glycemia by increasing liver glucokinase activity: an insulin independent effect. Nirav Dhanesha, Amit Joharapurkar, Gaurang Shah, Vipin Dhote, Samadhan Kshirsagar, Rajesh Bahekar, Mukul Jain (p. 140) Abstract / Article (PDF format) Modulatory effect of insulin on T cell receptor mediated calcium signaling is blunted in long lasting type 1 diabetes mellitus. Urszula Demkow, Paweł Winklewski, Olga Ciepiela, Katarzyna Popko, Anna Lipińska, Anna Kucharska, Beata Michalska, Maria Wąsik (p. 150) Abstract / Article (PDF format) Effects of valproic acid and levetiracetam on viability and cell cycle regulatory genes expression in the OVCAR-3 cell line. Patrycja Kwiecińska, Erik Taubol, Ewa Ł. Gregoraszczuk (p. 157) Abstract / Article (PDF format) Hematological effects of exposure to mixtures of selected ethylene glycol alkyl ethers in rats. Beata Starek-Świechowicz, Katarzyna Miranowicz-Dzierżawska, Wiesław Szymczak, Bogusława Budziszewska, Andrzej Starek (p. 166) Abstract / Article (PDF format) Modulation of Th1/Th2 cytokine production by selective and nonselective phosphodiesterase inhibitors administered to mice. Marianna Szczypka, Sebastian Ploch, Bożena Obmińska-Mrukowicz (p. 179) Abstract / Article (PDF format) Effect of ESR1 and ESR2 gene polymorphisms on rheumatoid arthritis treatment with methotrexate. Andrzej Pawlik, Violetta Dziedziejko, Mateusz Kurzawski, Krzysztof Safranow, Daniel Kotrych, Andrzej Bohatyrewicz (p. 185) Abstract / Article (PDF format) Protective effects of histamine H3-receptor ligands in schizophrenic behaviors in experimental models. Danish Mahmood, Razia Khanam, Krishna Kolappa Pilai, Mohd Akhtar (p. 191) Abstract / Article (PDF format) SHORT COMMUNICATIONS Influence of the phosphodiesterase type 5 inhibitor, sildenafil, on antidepressant-like activity of magnesium in the forced swim test in mice. Katarzyna Socała, Dorota Nieoczym, Ewa Poleszak, Piotr Wlaź (p. 205) Abstract / Article (PDF format) Influence of atorvastatin on serum amyloid A-low density lipoprotein complex in hypercholesterolemic patients. Kazuhiko Kotani, Toshiyuki Yamada, Michiaki Miyamoto, Shun Ishibashi, Nobuyuki Taniguchi, Alejandro Gugliucci (p. 212) Abstract / Article (PDF format) New conjugates of muramyl dipeptide and normuramyl dipeptide linked to tuftsin and retrotuftsin derivatives significantly influence their biological activity. Krystyna Dzierzbicka, Anna Wardowska, Małgorzata Rogalska, Piotr Trzonkowski (p. 217) Abstract / Article (PDF format) Abstract of the Fourth Conference on PROGRESS IN EPILEPSY AND ANTIEPILETIC DRUGS (p. 227) (PDF format)

CONTENTS (PDF format)

Zinc deficiency induces behavioral alterations in the tail suspension test in mice. Effect of antidepressants. Katarzyna Młyniec, Gabriel Nowak (p. 249) Abstract / Article (PDF format) Acute and repeated treatment with the 5-HT7 receptor antagonist SB 269970 induces functional desensitization of 5-HT7 receptors in rat hippocampus. Krzysztof Tokarski, Agnieszka Zelek-Molik, Beata Duszyńska, Grzegorz Satała, Bartosz Bobula, Magdalena Kusek, Piotr Chmielarz, Irena Nalepa, Grzegorz Hess (p. 256) Abstract / Article (PDF format) Neonatal serotonin (5-HT) depletion does not affect spatial learning and memory in rats. Agnieszka Piechal, Kamila Blecharz-Klin, Edyta Wyszogrodzka, Paulina Kołomańska, Paulina Rok-Bujko, Paweł Krząścik, Wojciech Kostowski, Ewa Widy-Tyszkiewicz, Małgorzata Filip, Roman Stefański (p. 266) Abstract / Article (PDF format) Flutamide treatment induces anxiolytic-like behavior in adult castrated rats. Anders I. Svensson (p. 275) Abstract / Article (PDF format) Antinociceptive and anti-inflammatory activities of a sulfated polysaccharide isolated from the green seaweed Caulerpa cupressoides. José A.G. Rodrigues, Edfranck de S.O. Vanderlei, Luana M.C.M. Silva, Ianna W.F. de Araújo, Ismael N.L. de Queiroz, Gabriela A. de Paula, Ticiana M. Abreu, Natássia A. Ribeiro, Mirna M. Bezerra, Helíada V. Chaves, Vilma Lima, Roberta J.B. Jorge, Helena S.A. Monteiro, Edda L. Leite, Norma M. B. Benevides (p. 282) Abstract / Article (PDF format) Evaluation and comparison of antinociceptive activity of aspartame with sucrose. Seema Rani, Mahesh C. Gupta (p. 293) Abstract / Article (PDF format) Antinociception by metoclopramide, ketamine and their combinations in mice. Fouad K. Mohammad, Banan Kh. Al-Baggou, Ahmed S. Naser (p. 299) Abstract / Article (PDF format) Influence of calcium channel blockers on anticonvulsant and antinociceptive activities of valproic acid in pentylenetetrazole-kindled mice. Mona F. El-Azab, Yasser M. Moustafa (p. 305) Abstract / Article (PDF format) Effect of hydrochlorothiazide on the anticonvulsant action of antiepileptic drugs against maximal electroshock-induced seizures in mice. Krzysztof Łukawski, Grażyna Świderska, Stanisław J. Czuczwar (p. 315) Abstract / Article (PDF format) Effects of different priming doses of fentanyl on fentanyl-induced cough: a double-blind, randomized, controlled study. ChengYong Gu, MaiTao Zhou, HongYe Wu, Fei Li, QiFeng Tang (p. 321) Abstract / Article (PDF format) Synthesis, anticonvulsant activity and 5-HT1A/5-HT7 receptors affinity of 1-[(4-arylpiperazin-1-yl)-propyl]-succinimides. Jolanta Obniska, Iwona Chlebek, Krzysztof Kamiński, Andrzej J. Bojarski, Grzegorz Satała (p. 326) Abstract / Article (PDF format) Significance of genetic polymorphism of CYP2D6 in the pathogenesis of systemic sclerosis. Małgorzata Barańska, Bożena Dziankowska-Bartkowiak, Elżbieta Waszczykowska, Mariola Rychlik-Sych, Jadwiga Skrętkowicz (p. 336) Abstract / Article (PDF format) C3435T Polymorphism of the ABCB1/MDR1 gene encoding P-glycoprotein in patients with inflammatory bowel disease in a Polish population. Michał Dudarewicz, Małgorzata Barańska, Mariola Rychlik-Sych, Radzisław Trzciński, Adam Dziki, Jadwiga Skrętkowicz (p. 343) Abstract / Article (PDF format) Antiarrhythmic effect of prolonged morphine exposure is accompanied by altered myocardial adenylyl cyclase signaling in rats. Jitka Skrabalova, Jan Neckar, Lucie Hejnova, Iveta Bartonova, Frantisek Kolar, Jiri Novotny (p. 351) Abstract / Article (PDF format) Effects of pantoprazole on dual antiplatelet therapy in stable angina pectoris patients after percutaneous coronary intervention. Katarzyna Mizia-Stec, Maciej Haberka, Magdalena Mizia, Bartosz Lasota, Marcin Kunecki, Klaudia Gieszczyk, Artur Chmiel, Jacek Najda, Sławomira Kyrcz-Krzemień, Zbigniew Gąsior (p. 360) Abstract / Article (PDF format) Single bout of endurance exercise increases NNMT activity in the liver and MNA concentration in plasma; the role of IL-6. Stefan Chłopicki, Marta Kurdziel, Magdalena Sternak, Małgorzata Szafarz, Joanna Szymura-Oleksiak, Karol Kamiński, Jerzy A. Żołądź. (p. 369) Abstract / Article (PDF format) Effectiveness of lipid-lowering therapy with statins for secondary prevention of atherosclerosis - guidelines vs. reality. Maria Bożentowicz-Wikarek, Piotr Kocełak, Mike Smertka, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek (p. 377) Abstract / Article (PDF format) Effects of thalidomide on the development of bone damage caused by prednisolone in rats. Kaczmarczyk-Sedlak, Maria Zych, Katarzyna Rotko, Lech Sedlak (p. 386) Abstract / Article (PDF format) Strontium ranelate treatment improves oxidative damage in osteoporotic rat model. Serap Yalin, Ozgun Sagýr, Ulku Comelekoglu, Mehmet Berköz, Pelin Eroglu (p. 396) Abstract / Article (PDF format) Restoration of immune system function is accelerated in immunocompromised mice by the B-cell-tropic isoxazole R-11. Michał Zimecki, Jolanta Artym, Maja Kocięba, Bożena Obmińska-Mrukowicz, Marcin Mączyński, Stanisław Ryng (p. 403) Abstract / Article (PDF format) Apoptotic gene expression under influence of fludarabine and cladribine in chronic lymphocytic leukemia-microarray study. Ida Franiak-Pietryga, Aleksandra Sałagacka, Henryk Maciejewski, Jerzy Z. Błoński, Maciej Borowiec, Marek Mirowski, Tadeusz Robak, Anna Korycka-Wołowiec (p. 412) Abstract / Article (PDF format) Pharmacokinetics and ocular disposition of paracetamol and paracetamol glucuronide in rabbits with diabetes mellitus induced by alloxan. Agnieszka Bienert, Agnieszka Kamińska, Jan Olszewski, Joanna Gracz, Tomasz Grabowski, Anna Wolc, Edmund Grześkowiak (p. 421) Abstract / Article (PDF format) Preclinical pharmacokinetics of radiolabelled hyaluronan. Milan Laznicek, Alice Laznickova, Dagmar Cozikova, Vladimir Velebny (p. 428) Abstract / Article (PDF format) SHORT COMMUNICATIONS Effect of resveratrol on scopolamine-induced cognitive impairment in mice. Rachna Gupta, Lalit K. Gupta, Pramod K. Mediratta, Swapan K. Bhattacharya (p. 438) Abstract / Article (PDF format) Differential effects of acute and repeated morphine treatment on kappa-opioid receptor mRNA levels in mesocorticolimbic system. Gang Yu, Hui Yan, Ze-Hui Gong (p. 445) Abstract / Article (PDF format) Serotonin 2A receptor gene (HTR2A) polymorphism in alcohol-dependent patients. Małgorzata Wrzosek, Andrzej Jakubczyk, Michał Wrzosek, Halina Matsumoto, Jacek Łukaszkiewicz, Kirk J. Brower, Marcin Wojnar (p. 449) Abstract / Article (PDF format) Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells. Yoshihiko Chiba, Kumiko Goto, Miwa Misawa (p. 454) Abstract / Article (PDF format) Abstracts of THE TWENTY FIRST DAYS OF NEUROPSYCHOPHARMACOLOGY (p. 459) (Title page) Plenary lectures (p. 461) Oral presentations (p. 464) Posters (p. 495)

CONTENTS (PDF format)

Review - L-NAME in the cardiovascular system - nitric oxide synthase activator? Jana Kopincová, Angelika Púzserová, Iveta Bernátová (p. 511) Abstract / Article (PDF format) Review - Prenatal tolerability of acetaminophen and other over-the-counter non-selective cyclooxygenase inhibitors. Franciszek Burdan, Elżbieta Starosławska, Justyna Szumiło (p. 521) Abstract / Article (PDF format) Some dopaminergic genes polymorphisms are not associated with response to antipsychotic drugs in schizophrenic patients. Piotr Tybura, Agnieszka Samochowiec, Aleksander Beszlej, Anna Grzywacz, Monika Mak, Dorota Frydecka, Przemysław Bieńkowski, Paweł Mierzejewski, Andrzej Potemkowski, Jerzy Samochowiec (p. 528) Abstract / Article (PDF format) Baclofen influences acquisition and MMP-2, MMP-9 levels in the hippocampus of rats after hypoxia. Halina Car, Piotr Michaluk (p. 536) Abstract / Article (PDF format) Morphine-induced place preference affects mRNA expression of G protein alpha subunits in rat brain. Agnieszka Zelek-Molik, Adam Bielawski, Grzegorz Kreiner, Piotr Popik, Jerzy Vetulani, Irena Nalepa (p. 546) Abstract / Article (PDF format) Citalopram decreases tryptophan 2,3-dioxygenase activity and brain 5-HT turnover in swim stressed rats. Iffat Ara, Samina Bano (p. 558) Abstract / Article (PDF format) Time course of zinc deprivation-induced alterations of mice behavior in the forced swim test. Katarzyna Młyniec, Claire Linzi Davies, Bogusława Budziszewska, Włodzimierz Opoka, Witold Reczyński, Magdalena Sowa-Kućma, Urszula Doboszewska, Andrzej Pilc, Gabriel Nowak (p. 567) Abstract / Article (PDF format) Pregabalin antinociception and its interaction with tramadol in acute model of pain. Manzumeh Shamsi Meymandi, Fariborz Keyhanfar (p. 576) Abstract / Article (PDF format) Deposition of ethyl glucuronide in WHP rat hair after chronic ethanol intake. Anna Małkowska, Mirosław Szutowski, Wanda Dyr (p. 586) Abstract / Article (PDF format) Biochemical and histologic study of lethal cisplatin nephrotoxicity prevention by mirtazapine. Mustafa Talip Sener, Ebru Sener, Adem Tok, Beyzagul Polat, Irfan Cinar, Harun Polat, Fatih Akcay, Halis Suleyman (p. 594) Abstract / Article (PDF format) Comparison of the effects of valproic acid and levetiracetam on apoptosis in the human ovarian cancer cell ine OVCAR-3. Patrycja Kwiecińska, Erik Tauboll, Ewa Łucja Gregoraszczuk (p. 603) Abstract / Article (PDF format) Upregulation of intrinsic apoptotic pathway in NSAIDs mediated chemoprevention of experimental lung carcinogenesis. Shruti Setia, Sankar N. Sanyal (p. 615) Abstract / Article (PDF format) Proton pump (H+/K+-ATPase) inhibitors weaken the protective effect of alendronate on bone mechanical properties in estrogen-deficient rats. Maria Pytlik, Urszula Cegieła, Joanna Folwarczna, Barbara Nowińska (p. 625) Abstract / Article (PDF format) Influence of short-term L-arginine supplementation on carbohydrate balance in rats with ischemia-reperfusion syndrome. Hanna Krauss, Paweł Bogdański, Przemysław Sosnowski, Joanna Suliburska, Anna Jabłecka, Rafał Jastak, Maciej Sassek, Paweł Maćkowiak, Artur Cieślewicz, Danuta Pupek-Musialik (p. 635) Abstract / Article (PDF format) Granulocyte colony-stimulating factor improves early remodeling in isoproterenol-induced cardiac injury in rats. Ludimila Forechi, Marcelo P. Baldo, Diana Meyerfreund, José G. Mil. (p. 643) Abstract / Article (PDF format) Mechlorethamine (NTG) effects on the erythrocytic and leukocytic blood parameters during experimentally induced pleuritis in rats. Ireneusz Całkosiński, Joanna Rosińczuk-Tonderys, Katarzyna Dzierzba, Justyna Bazan, Monika Całkosińska, Jacek Majda, Maciej Dobrzyński, Agnieszka Bronowicka-Szydełko (p. 650) Abstract / Article (PDF format) Effect of total and partial nephrectomy on the elimination of ciprofloxacin in humans. Edyta Szałek, Wojciech Połom, Agnieszka Karbownik, Tomasz Grabowski, Agnieszka Konkołowicz, Anna Wolc, Marcin Matuszewski, Kazimierz Krajka, Edmund Grześkowiak (p. 673) Abstract / Article (PDF format) Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics. Azman Abdullah, Neil R. Kitteringham, Rosalind E. Jenkins, Christopher Goldring, Larry Higgins, Masayuki Yamamoto, John Hayes, B. Kevin Park (p. 680) Abstract / Article (PDF format) Potential hepato-protective effect of a-tocopherol or simvastatin in aged rats. Mai M. Helmy (p. 698) Abstract / Article (PDF format) SHORT COMMUNICATIONS Involvement of NMDA receptors in the antidepressant-like action of adenosine. Manuela P. Kaster, Daniele G. Machado, Adair R.S. Santos, Ana Lúcia S. Rodrigues (p. 706) Abstract / Article (PDF format) Inhibitory effect of antidepressant drugs on contact hypersensitivity reaction. Marta Kubera, Katarzyna Curzytek, Monika Majewska-Szczepanik, Marian Szczepanik, Katarzyna Marcińska, Włodzimierz Ptak, Monika Leśkiewicz, Michael Maes, Agnieszka Basta-Kaim, Bogusława Budziszewska, Jan Detka, Weronika Duda, Władysław Lasoń (p. 714) Abstract / Article (PDF format) Synergistic interaction of pregabalin with the synthetic cannabinoid WIN 55,212-2 mesylate in the hot-plate test in mice: an isobolographic analysis. Jarogniew J. Łuszczki, Magdalena Florek-Łuszczki (p. 723) Abstract / Article (PDF format) Action of calcium antagonists and agonists on isolated human thoracic arteries used for coronary artery bypass grafting. Vida Garaliene, Vygantas Barsys, Povilas Jakuška, Rimantas Benetis (p. 733) Abstract / Article (PDF format) Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. Yuk-Man Leung, Kar-Lok Wong, Ka-Shun Cheng, Chang-Shin Kuo, Tzu-Hui Su, Yu-Wen Chen, Tzu-Hurng Cheng (p. 739) Abstract / Article (PDF format) Kynurenic acid enhances expression of p21 Waf1/Cip1 in colon cancer HT-29 cells. Katarzyna Walczak, Waldemar A. Turski, Wojciech Rzeski (p. 745) Abstract / Article (PDF format) CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells. Jonathon C. Arnold, Phoebe Hone, Michele L. Holand, John D. Alen (p. 751) Abstract / Article (PDF format)

CONTENTS (PDF format)

Review - Prediction of enzyme activity with neural network models based on electronic and geometrical features of substrates. Maciej Szaleniec (p. 761) Abstract / Article (PDF format) Review - Potential pitfalls of propofol target controlled infusion delivery related to its pharmacokinetics and pharmacodynamics. Agnieszka Bienert, Paweł Wiczling, Edmund Grześkowiak, Jacek B. Cywiński, Krzysztof Kusza (p. 782) Abstract / Article (PDF format) Antidepressant-like activity of ellagic acid in unstressed and acute immobilization-induced stressed mice. Dinesh Dhingra, Ritu Chhillar (p. 796) Abstract / Article (PDF format) Influence of long-term administration of rutin on spatial memory as well as the concentration of brain neurotransmitters in aged rats. Justyna Pyrzanowska, Agnieszka Piechal, Kamilla Blecharz-Klin, Ilona Joniec-Maciejak, Alicja Zobel, Ewa Widy-Tyszkiewicz (p. 808) Abstract / Article (PDF format) Synthesis and pharmacological properties of new GABA uptake inhibitors. Kinga Sałat, Anna Więckowska, Krzysztof Więckowski, Georg C. Höfner, Jacek Kamiński, Klaus T. Wanner, Barbara Malawska, Barbara Filipek, Katarzyna Kulig (p. 817) Abstract / Article (PDF format) Effect of benzothiazole/piperazine derivatives on intracerebroventricular streptozotocin-induced cognitive deficits. Ümide Demir Özkay, Özgür Devrim Can, Yusuf Özkay, Yusuf Öztürk (p. 834) Abstract / Article (PDF format) Mangiferin ameliorates 6-hydroxydopamine-induced cytotoxicity and oxidative stress in ketamine model of schizophrenia. Vietla S. Rao, Ana C. Carvalho, Maria Teresa S. Trevisan, Geanne M. Andrade, Helio V. Nobre-Júnior, Manoel O. Moraes, Hemerson I. Magalhaes, Talita C. Morais, Flavia A. Santos (p. 848) Abstract / Article (PDF format) Comparative behavioral and neurochemical studies of R- and S-1-methyl-1,2,3,4-tetrahydroisoquinoline stereoisomers in the rat. Agnieszka Wąsik, Irena Romańska, Jerzy Michaluk, Lucyna Antkiewicz-Michaluk (p. 857) Abstract / Article (PDF format) Decreased analgesic effect of morphine, but not buprenorphine, in patients with advanced P-glycoprotein+ cancers. Jun Wang, Bing Cai, Dong-Xiao Huang, Shu-DongYang, Lin Guo (p. 870) Abstract / Article (PDF format) Effect of angiotensin II type 1 receptor blocker on osteoporotic rat femurs. Baris Ozgur Donmez, Semir Ozdemir, Mehmet Sarikanat, Nazmi Yaras, Pýnar Koc, Necdet Demir, Binnur Karayalcin, Nurettin Oguz (p. 878) Abstract / Article (PDF format) Berberine inhibits dyslipidemia in C57BL/6 mice with lipopolysaccharide induced inflammation. Hong-Bo Xiao, Zhi-Liang Sun, Heng-Bo Zhang, Da-Sheng Zhang (p. 889) Abstract / Article (PDF format) Ethanol and nitric oxide modulate expression of glucocorticoid receptor in the rat adrenal cortex. Dragoslava Djikić, Mirela Budeč, Sanja Vranješ-Djurić, Vera Todorović, Neda Drndarević, Sanja Vignjević, Olivera Mitrović (p. 896) Abstract / Article (PDF format) Effect of exposure to fluoride and acetaminophen on oxidative/nitrosative status of liver and kidney in male and female rats. Iwona Inkielewicz-Stępniak, Narcyz Knap (p. 902) Abstract / Article (PDF format) Epigallocatechin-3-gallate inhibits angiotensin II and interleukin-6-induced C-reactive protein production in macrophages. Ming Li, Jun-Tian Liu, Xiao-Ming Pang, Chun-Jie Han, Jun-Jun Mao (p. 912) Abstract / Article (PDF format) Epicutaneous immunization with hapten-conjugated protein antigen alleviates contact sensitivity mediated by three different types of effector cells Monika Majewska-Szczepanik, Anna Strzępa, Iwona Drożyńska, Sylwia Motyl, Tomasz Banach, Marian Szczepanik (p. 919) Abstract / Article (PDF format) Expression of genes involved in xenobiotic metabolism and transport in end-stage liver disease: up-regulation of ABCC4 and CYP1B1. Mateusz Kurzawski, Violetta Dziedziejko, Mariola Post, Maciej Wójcicki, Elżbieta Urasińska, Janusz Miętkiewski, Marek Droździk (p. 927) Abstract / Article (PDF format) In vivo and in vitro evaluation of the estrogenic properties of the 17b-(butylamino)-1,3,5(10)- estratrien-3-ol (buame) related to 17beta-estradiol. Cristina Lemini, Martha Medina, María E. Avila, Pablo Cruz-Lemini, Enrique Canchola, René Santillan, Ana E. Lemus (p. 940) Abstract / Article (PDF format) Modulation of ghrelin axis influences the growth of colonic and prostatic cancer cells in vitro. Hanna Ławnicka, Gabriela Mełeń-Mucha, Ewelina Motylewska, Sławomir Mucha, Henryk Stępień (p. 951) Abstract / Article (PDF format) SHORT COMMUNICATIONS Wheel running decreases the positive reinforcing effects of heroin. Mark A. Smith, Elizabeth G. Pitt (p. 960) Abstract / Article (PDF format) Influence of acute and subchronic oral administration of dehydroepiandrosterone (DHEA) on nociceptive threshold in rats. Emilia Gąsińska, Magdalena Bujalska-Zadrożny, Monika Sar, Helena Makulska-Nowak (p. 965) Abstract / Article (PDF format) Influence of 5-(3-chlorophenyl)-4-(4-methylphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione on the anticonvulsant action of 4 classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model. Jarogniew J. Łuszczki, Tomasz Plech, Monika Wujec (p. 970) Abstract / Article (PDF format) In vitro effects of serotonin and noradrenaline reuptake inhibitors on human platelet adhesion and coagulation. Ida Hallbäck, Staffan Hägg, Andreas C. Eriksson, Per A. Whiss (p. 979) Abstract / Article (PDF format) Comparative study of the anti-edematogenic effects of anethole and estragole. Edson L. Ponte, Paloma L. Sousa, Maria V. A. P. Rocha, Pedro M. G. Soares, Andrelina N. Coelho-de-Souza, José H. Leal-Cardoso, Ana M. S. Assreuy (p. 984) Abstract / Article (PDF format) Verapamil-induced autophagy-like process in colon adenocarcinoma COLO 205 cells; the ultrastructural studies. Beata Pająk, Elżbieta Kania, Barbara Gajkowska, Arkadiusz Orzechowski (p. 991) Abstract / Article (PDF format) LETTER TO THE EDITOR Ezetimibe - a new approach in hypercholesterolemia management. Michael S. Kostapanos, Moses S. Elisaf, Dimitri P. Mikhailidis (p. 997) PDF format

CONTENTS (PDF format)

Minireview - Synthetic immunostimulatory oligonucleotides in experimental and clinical practice. Paweł Bodera, Wanda Stankiewicz, Janusz Kocik (p. 1003) Abstract / Article (PDF format) Review - The multidrug transporter P-glycoprotein in pharmacoresistance to antiepileptic drugs. Karolina M. Stępień, Michał Tomaszewski, Joanna Tomaszewska, Stanisław J. Czuczwar (p. 1011) Abstract / Article (PDF format) Review - Nanoparticles as drug delivery systems. Agnieszka Z. Wilczewska, Katarzyna Niemirowicz, Karolina H. Markiewicz, Halina Car (p. 1020) Abstract / Article (PDF format) Review - Role of the SOCS in monocytes/macrophages-related pathologies. Are we getting closerto a new pharmacological target? Krzysztof Łabuzek, Dariusz Suchy, Bożena Gabryel, Olga Pierzchała, Bogusław Okopień (p. 1038) Abstract / Article (PDF format) Review - 11beta-Hydroxysteroid dehydrogenase type 1: potential therapeutic target for metabolic syndrome. Amit Joharapurkar, Nirav Dhanesha, Gaurang Shah, Rajendra Kharul, Mukul Jain (p. 1055) Abstract / Article (PDF format) Involvement of cholinergic receptors in the different stages of memory measured in the modified elevated plus maze test in mice. Marta Kruk-Słomka, Barbara Budzyńska, Grażyna Biała (p. 1066) Abstract / Article (PDF format) Characterization of motor, depressive-like and neurochemical alterations induced by a short-term rotenone administration. Lívia H. Morais, Marcelo M.S. Lima, Bruno J. Martynhak, Ronise Santiago, Tatiane T. Takahashi, Deborah Ariza, Janaína K. Barbiero, Roberto Andreatini, Maria A.B.F. Vital (p. 1081) Abstract / Article (PDF format) Effects of morphine on immediate-early gene expression in the striatum of C57BL/6J and DBA/2J mice. Barbara Ziółkowska, Michał Korostyński, Marcin Piechota, Jakub Kubik, Ryszard Przewłocki (p. 1091) Abstract / Article (PDF format) Potential role of licofelone, minocycline and their combination against chronic fatigue stress induced behavioral, biochemical and mitochondrial alterations in mice. Anil Kumar, Aditi Vashist, Puneet Kumar, Harikesh Kalonia, Jitendriya Mishra (p. 1105) Abstract / Article (PDF format) Tolerance liability of diazepam is dependent on the dose used for protracted treatment. Jovana Divljaković, Marija Milić, Tamara Timić, Miroslav M. Savić (p. 1116) Abstract / Article (PDF format) Influence of DRD2 and ANKK1 polymorphisms on the manifestation of withdrawal syndrome symptoms in alcohol addiction Anna Grzywacz, Andrzej Jasiewicz, Iwona Małecka, Aleksandra Suchanecka, Elżbieta Grochans, Beata Karakiewicz, Agnieszka Samochowiec, Przemysław Bieńkowski, Jerzy Samochowiec (p. 1126) Abstract / Article (PDF format) Trazodone reduces the anticonvulsant action of certain classical antiepileptics in the mouse maximal electroshock model. Kinga K. Borowicz, Elwira Gurdziel, Stanisław J. Czuczwar (p. 1135) Abstract / Article (PDF format) New neostigmine-based behavioral mouse model of abdominal pain. Jakub Fichna, Tamia Lapointe, Kevin Chapman, Anna Janecka, Nathalie Vergnole, Christophe Altier, Martin A. Storr (p. 1146) Abstract / Article (PDF format) Anti-inflammatory and antinociceptive effects of 6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine in mice. Hai-Ling Yu, Feng-Zhang, Ying-Jun Li, Guo-Hua Gong, Zhe-Shan Quan (p. 1155) Abstract / Article (PDF format) Synergistic neurotoxicity of oxygen-glucose deprivation and tetrabromobisphenol A in vitro: role of oxidative stress. Elżbieta Ziemińska, Aleksandra Stafiej, Beata Toczyłowska, Jerzy W. Łazarewicz (p. 1166) Abstract / Article (PDF format) Evaluation of the antioxidative properties of lipoxygenase inhibitors. Grzegorz A. Czapski, Kinga Czubowicz, Robert P. Strosznajder (p. 1179) Abstract / Article (PDF format) Oroxylin A, a classical natural product, shows a novel inhibitory effect on angiogenesis induced by lipopolysaccharide. Xiuming Song, Yan Chen, Yajing Sun, Biqi Lin, Yansu Qin, Hui Hui, Zhiyu Li, Qidong You, Na Lu, Qinglong Guo (p. 1189) Abstract / Article (PDF format) The influence of opioids on the humoral and cell-mediated immune responses in mice. The role of macrophages. Iwona Filipczak-Bryniarska, Bernadeta Nowak, Emilia Sikora, Katarzyna Nazimek, Jarosław Woroń, Jerzy Wordliczek, Krzysztof Bryniarski (p. 1200) Abstract / Article (PDF format) Anti-allergic activity of emodin on IgE-mediated activation in RBL-2H3 cells. Weimin Wang, Qin Zhou, Lu Liu, Keqin Zou (p. 1216) Abstract / Article (PDF format) Effect of mononuclear cells versus pioglitazone on streptozotocin-induced diabetic nephropathy in rats. Riham E. Masoad, Mohamed M.S. Ewais, Mona K. Tawfik, Hwayda S. Abd El-Al (p. 1223) Abstract / Article (PDF format) Contribution of the beta-ureidopropionase (UPB1) gene alterations to the development of fluoropyrimidine-related toxicity. Julie Fidlerova, Petra Kleiblova, Stanislav Kormunda, Jan Novotny, Zdenek Kleibl (p. 1234) Abstract / Article (PDF format) Interactions between drugs and sulforaphane modulate the drug metabolism enzymatic system. Katarzyna Lubelska, Małgorzata Milczarek, Karolina Modzelewska, Jolanta Krzysztoń-Russjan, Krzysztof Fronczyk, Katarzyna Wiktorska. (p. 1243) Abstract / Article (PDF format) SHORT COMMUNICATIONS Antidepressant drugs promote the heterodimerization of the dopamine D2 and somatostatin Sst5 receptors - fluorescence in vitro studies. Kinga Szafran, Sylwia Łukasiewicz, Agata Faron-Górecka, Magdalena Kolasa, Maciej Kuśmider, Joanna Solich, Marta Dziedzicka-Wasylewska (p. 1253) Abstract / Article (PDF format) Sildenafil, a phosphodiesterase type 5 inhibitor, reduces antidepressant-like activity of paroxetine in the forced swim test in mice. Katarzyna Socała, Dorota Nieoczym, Elżbieta Wyska, Ewa Poleszak, Piotr Wlaź (p. 1259) Abstract / Article (PDF format) Modification of morphine analgesia by venlafaxine in diabetic neuropathic pain model. Krystyna Cegielska-Perun, Magdalena Bujalska-Zadrożny, Helena E. Makulska-Nowak (p. 1267) Abstract / Article (PDF format) Increased concentration of metronidazole and its hydroxy metabolite in colon cancer in women. Anna Sadowska, Bogusław Kędra, Dariusz Cepowicz, Lech Rodziewicz, Anna Fiedorowicz, Sławomir Prokopiuk, Wojciech Miltyk, Halina Car (p. 1276) Abstract / Article (PDF format)

CONTENTS (PDF format)

Review - Flowers for Algernon: steroid dysgenesis, epigenetics and brain disorders. Bryan K. Sanders (p. 1285) Abstract / Article (PDF format) Review - Drug therapy in autism: a present and future perspective. Baldeep Kumar, Ajay Prakash, Rakesh K. Sewal, Bikash Medhi, Manish Modi (p. 1291) Abstract / Article (PDF format) Review - Stress- and antidepressant treatment-induced modifications of 5-HT7 receptor functions in the rat brain. Krzysztof Tokarski, Bartosz Bobula, Małgorzata Grzegorzewska-Hiczwa, Magdalena Kusek, Grzegorz Hess (p. 1305) Abstract / Article (PDF format) Effects of the histamine H3 receptor antagonist ABT-239 on cognition and nicotine-induced memory enhancement in mice. Marta Kruk, Joanna Miszkiel, Andrew C. McCreary, Edmund Przegaliński, Małgorzata Filip, Grażyna Biała (p. 1316) Abstract / Article (PDF format) Protective effect of HMG CoA reductase inhibitors against running wheel activity induced fatigue, anxiety like behavior, oxidative stress and mitochondrial dysfunction in mice. Anil Kumar, Aditi Vashist, Puneet Kumar, Harikesh Kalonia, Jitendriya Mishra (p. 1326) Abstract / Article (PDF format) LC/MS/MS evaluation of cocaine and its metabolites in different brain areas, peripheral organs and plasma in cocaine self-administering rats. Beata Bystrowska, Przemysław Adamczyk, Andrzej Moniczewski, Magdalena Zaniewska, Kjell Fuxe, Małgorzata Filip (p. 1337) Abstract / Article (PDF format) Concomitant use of tramadol and venlafaxine - evaluation of antidepressant-like activity and other behavioral effects in rats. Danuta Szkutnik-Fiedler, Krzysztof Kus, Monika Balcerkiewicz, Edmund Grześkowiak, Elżbieta Nowakowska, Kinga Burda, Piotr Ratajczak, Czesław Sadowski (p. 1350) Abstract / Article (PDF format) Chronic impairment of the vagus nerve function leads to inhibition of dopamine but not serotonin neurons in rat brain structures. Agata Ziomber, Piotr Thor, Anna Krygowska-Wajs, Tomasz Załęcki, Marek Moskała, Irena Romańska, Jerzy Michaluk, Lucyna Antkiewicz-Michaluk. (p. 1359) Abstract / Article (PDF format) Effects of co-administration of fluoxetine and risperidone on properties of peritoneal and pleural macrophages in rats subjected to the forced swimming test. Adam Roman, Justyna Kuśmierczyk, Ewa Klimek, Zofia Rogóż, Irena Nalepa (p. 1368) Abstract / Article (PDF format) Effect of repeated restraint on homotypic stress-induced nitric oxide synthases expression in brain structures regulating HPA axis. Anna Gądek-Michalska, Joanna Tadeusz, Paulina Rachwalska, Jadwiga Spyrka, Jan Bugajski (p. 1381) Abstract / Article (PDF format) Effect of co-treatment with fluoxetine or mirtazapine and risperidone on the active behaviors and plasma corticosterone concentration in rats subjected to the forced swim test. Zofia Rogóż, Marcin Kabziński, Witold Sadaj, Paulina Rachwalska, Anna Gądek-Michalska (p. 1391) Abstract / Article (PDF format) Maternal immune activation leads to age-related behavioral and immunological changes in male rat offspring - the effect of antipsychotic drugs. Agnieszka Basta-Kaim, Ewa Szczęsny, Monika Leśkiewicz, Katarzyna Głombik, Joanna Ślusarczyk, Bogusława Budziszewska, Magdalena Regulska, Marta Kubera, Wojciech Nowak, Krzysztof Wędzony, Władysław Lasoń (p. 1400) Abstract / Article (PDF format) Effect of classic and atypical neuroleptics on cytochrome P450 3A (CYP3A) in rat liver. Jacek Wójcikowski, Anna Haduch, Władysława A. Daniel (p. 1411) Abstract / Article (PDF format) Kavain analogues as potential analgesic agents. Elaine C. Kormann, Patricia de Aguiar Amaral, Michele David, Vera L. Eifler-Lima, Valdir Cechinel Filho, Fátima de Campos Buzzi (p. 1419) Abstract / Article (PDF format) Level of S100B protein, neuron specific enolase, orexin A, adiponectin and insulin-like growth factor in serum of pediatric patients suffering from sleep disorders with or without epilepsy. Marek Kaciński, Bogusława Budziszewska, Władysław Lasoń, Anna Zając, Barbara Skowronek-Bała, Monika Leśkiewicz, Alicja Kubik, Agnieszka Basta-Kaim (p. 1427) Abstract / Article (PDF format) Influence of specific endothelin-1 receptor blockers on hemodynamic parameters and antioxidant status of plasma in LPS-induced endotoxemia. Aleksandra Piechota-Polańczyk, Anna Gorąca (p. 1434) Abstract / Article (PDF format) Function of the hypothalamo-neurohypophysial system in rats with myocardial infarction is modified by melatonin. Joanna Ciosek, Jacek Drobnik (p. 1442) Abstract / Article (PDF format) Brain nitric oxide synthases in the interleukin-1beta-induced activation of hypothalamic-pituitary-adrenal axis. Anna Gądek-Michalska, Joanna Tadeusz, Paulina Rachwalska, Jadwiga Spyrka, Jan Bugajski (p. 1455) Abstract / Article (PDF format) Different effects of perindopril and enalapril on monocyte cytokine release in coronary artery disease patients with normal blood pressure. Robert Krysiak, Bogusław Okopień (p. 1466) Abstract / Article (PDF format) Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats. Hamid Soraya, Arash Khorrami, Afagh Garjani, Nasrin Maleki-Dizaji, Alireza Garjani (p. 1476) Abstract / Article (PDF format) Epicutaneous immunization with protein antigen induces antigen-non-specific suppression of CD8 T cell mediated contact sensitivity. Magdalena Zemelka-Wiącek, Monika Majewska-Szczepanik, Włodzimierz Ptak, Marian Szczepanik (p. 1485) Abstract / Article (PDF format) Epicutaneous immunization with protein antigen TNP-Ig alleviates TNBS-induced colitis in mice. Monika Majewska-Szczepanik, Marta Góralska, Katarzyna Marcińska, Magdalena Zemelka-Wiącek, Anna Strzępa, Iwona Dorożyńska, Marian Szczepanik (p. 1497) Abstract / Article (PDF format) Resveratrol improves diabetic retinopathy possibly through oxidative stress - nuclear factor kappaB - apoptosis pathway. Farhad Ghadiri Soufi, Daryoush Mohammad-nejad, Hamid Ahmadieh (p. 1505) Abstract / Article (PDF format) Guanidine-reactive agent phenylglyoxal induces DNA damage and cancer cell death. José M. Calderón-Montano, Estefanía Burgos-Morón, Manuel L. Orta, Nuria Pastor, Concepción Perez-Guerrero, Caroline A. Austin, Santiago Mateos, Miguel López-Lázaro (p. 1515) Abstract / Article (PDF format) EP3 receptor-mediated contraction of human pulmonary arteries and inhibition of neurogenic tachycardia in pithed rats. Hanna Kozłowska, Marta Baranowska-Kuczko, Eberhard Schlicker, Mirosław Kozłowski, Agnieszka Zakrzeska, Emilia Grzęda, Barbara Malinowska (p. 1526) Abstract / Article (PDF format) Possible mechanism by which zinc protects the testicular function of rats exposed to cigarette smoke. Michele K. Sankako, Patricia C. Garcia, Renata C. Piffer, Bruna Dallaqua, Débora C. Damasceno, Oduvaldo C. M. Pereira (p. 1537) Abstract / Article (PDF format) Effect of 4-methylpyrazole on antioxidant enzyme status and lipid peroxidation in the liver of rats after exposure to ethylene glycol and ethyl alcohol. Karina Sommerfeld, Barbara Zielińska-Psuja, Jędrzej Przystanowicz, Joanna Kowalówka-Zawieja, Jerzy Orłowski (p. 1547) Abstract / Article (PDF format) Sunitinib in combination with clarithromycin or azithromycin - is there a risk of interaction or not? Edyta Szałek, Agnieszka Karbownik, Wojciech Połom, Marcin Matuszewski, Katarzyna Sobańska, Hanna Urjasz, Tomasz Grabowski, Anna Wolc, Edmund Grześkowiak (p. 1554) Abstract / Article (PDF format) Study of ABCB1 polymorphism frequency in breast cancer patients from Poland. Błażej Rubiś, Hanna Hołysz, Wojciech Barczak, Robert Gryczka, Mariusz Łaciński, Paweł Jagielski, Anna Czernikiewicz, Anna Półrolniczak, Aneta Wojewoda, Katarzyna Perz, Paweł Białek, Karolina Morze, Zuzanna Kanduła, Natalia Lisiak, Przemysław M. Mrozikiewicz, Sylwia Grodecka-Gazdecka, Maria Rybczyńska (p. 1560) Abstract / Article (PDF format) SHORT COMMUNICATIONS Effect of co-treatment with mirtazapine and risperidone in animal models of the positive symptoms of schizophrenia in mice. Zofia Rogóż (p. 1567) Abstract / Article (PDF format) Is rapid effect of thyroxine on GABAergic IPSCs purely postsynaptic? Maksim Storozhuk, Svetlana Ivanova, Lyudmila Nikolaenko, Oleg Krishtal (p. 1573) Abstract / Article (PDF format) Autoinduction of the metabolism of phenothiazine neuroleptics in a primary culture of human hepatocytes. Jacek Wójcikowski, Patrick Maurel, Władysława A. Daniel (p. 1578) Abstract / Article (PDF format)